参考文献一覧

(*1)Vignery A,Baron R : Dynamic histomorphometry of alveolar bone remodeling in the adult rat.Anat Rec196:191-200,1980
(*2)Oguro I,Ozawa H : The histochemicalization of acid phosphatase activity in BMU.JBone Miner Metab 6:190-195,1988
(*3)Oguro I,Ozawa H : Cytochemical studies of the cellualr events in bone remodeling : Cytological evidence for a coupling mechanism.JBone Miner Metab 7:30-6,1989
(*4)Scott BL : Thymidine-3H electron microscope radioautography of osteogenic cells in the fetal rat.J Cell Biol 35:115-126,1967
(*5)Young RW : Cell proliferation and specialization during endochondral osteogenesis in young rats.J Cell Biol 14:357-370,1962
(*6)K hoshi, N Amizukaet al. : Immunolocalzation of Tissue Non-Specific Alkaline Phosphatase in Mice. Histochem.Cell Biol 107:183-191,1997
(*7)Fleish H, Neuman WF Mechanisms of calcification : role of collagen, polyphospkates,and phosphate.AmJ Physiol 200:1296-1300,1961
(*8)小澤英治, 網塚憲生 : Bone Cells の構造と機能, 日本臨床 52:12,1996
(*9)Hunter GK, Goldberg HA : Nucleation of hydroxyapatite by bone sialoprotein. Proc Natl Acad Sci USA 90:8562-8565,1993
(*10)Mark MP ,Butler WT et al. : developmental expression of 44-kDa phosphoprotein (Osteopontin) and bone g-carboxyglutamic acid (Gla)-containin protein (0steocalcin) in calcifying tissues of rat. Differentiation 37:123-136,1988
(*11)Bosky AL, Maresca M et al. : Osteopontin-hydroxyapatite interaction in vitro : Inhibition of hydroxyapatite formation and growth in a gelatin-gel.Bone Miner 22: 147-159,1993
(*12)Ikeda T, Nomura S et al. : In situ hybridization of bone matrix protein undecalcifind about rat bome sections.J.Histochem.Cytohem 40:1079-1088,1992
(*13)Nomura S et al. : Developmental expression of 2ar(osteopontin)and SPARC(osteonectin)RNA as revealed by in situ hybridization. J Cell Biol 106:441-450,1988
(*14)McKee MD, Nanci A : Post-embedding colloidal-gold mmunocytochemistry of noncollagenous extracellualr matrix proteins in mineralized tissues.Microsc Res Tech 31:44-62,1995
(*15)McKee MD, Nanci A : Osteopontin at mineralized tisue interfaces in bone teeth and osteointegrated implants: Ultrastructural distribution and implication for mineralized tissue formation, turnover and repair.Microsc Res Tech 33:141-164,1996
(*16)McKee MD, Farachh-Carson MC et al. : Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and a2HS-glycoprotein)proteins in rat bone.JBone Miner Res 8:485-496,1993
(*17)Doty SB. : morphological evidence of gap junction between bone cells. Calcif Tissue Int 33:509-512,1981
(*18)Ejiri S. Ozawa H : Scanning electron microscopic observations of rat tibia using the HCI-collagenase method.Arch histol jap 45:399-404,1982
(*19)Palumbo C, Palazzini S et al. : Morphological study of intercellular junctions during osteocyte differentiation. Bone 11:401-406,1990
(*20)Rouleau MF et al. : In vivo distribution of parathyroid hormone receptorsin bone : evidence that a predominant ossecus target cell is not the mature osteoblast. Endocrinology 123:187-191,1988
(*21)Rouleau MF, Mitchell et al. : Characterization of the major parathyroid hormon target cell in the endostealmetaphysis of rat long bones. J Bone Miner Res 5:1043-1053,1990
(*22)Amizuka N, Karaplis AC, et al. : Haploinsufficiency of parathyroid hormone-reptide (PTHrP)results in abnormalpost-natal bone development. Develop Biol 175:166-176,1996
(*23)Irie K, Ozawa H : Immunohistochistochemical localization of parathyroid hor-mone l palathyroid hormone-related peptide receptor in rat tibiae. J Bone Miner metab 14:10-14,1996
(*24)Karaplis AC, Luz A et al. : Lethal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.Genes Dev 8:277-289,1994
(*25)Amizuka N, Henderson JE et al. : parathyroid hormone-related peptide (PTHrP)-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J Cell Biol 126:1611-1623,1994
(*26)Amizuka N, Henderson JE et al. : Programmed cell death of chondrocytes and aberrant chondrogesis in mice homozygous for parathyroid hormone-related peptide(PTHrP)gene deletion. Endocrinology 137:5055-5067,1996
(*27)Juppner H, Abou-Samra A-B et al. : AG protein-linked receptor for parathyroid hormone and parathyroid hormone-related,Science 254:1024-1026,1991
(*28)Schipani E, Klaus K et al. : A constitutive mutant PTH-PTHrP receptor in jansen -type metaphyseal chondrodisplasia. Science 268:98-100,1995
(*29)McCuaig KA, Clarke JC, et al. : Molecular cloning of the gene en-coding the mouse parathyroid hormone/parathyroid hormone-related pep-tide receptor. Proc Nat Acad Sci USA 91:5051-5055,1994
(*30)McCuaig KA, Lee H et al. : Parathyroid hormone/parathyroid hormone related peptide receptor gene transcripts are expressed from tissue-specific and ubiq-uitous promoters. Nucleic Acids Res 23:1948-1955,1996
(*31)Amizuka N, Lee HS et al. : Cell-specific expression of the parathyroid hormone(PTH)/PTH-related peptide receptor gene in rat kidney from kidney-specific and ubiquitous promoters. Endocrinology 138:469-481,1997
(*32)Fukumoto S, Suzukawa M et al. : Cloning and tissue specific usage of 5 -untranslated exons of human parathyroid hormone(PTH)/PTH-related protein (PTHRP) receptor gene.J Bone Miner Res 11:s301,1996
(*33)Lanske B, Karaplis AC et al. : PTH/PTHrP receptor in early development and Indian fedgehog-regulated bone growth. Science 273:663-666,1996
(*34)M Tanaka, N Amizuka et al. : Histochemical Examination of Ectopic Bone Formation Induced in Bone Marrw.J Bone Min Metab in press. 1997
(*35)Amizuka N, Yamada M et al. : Morpological of bone synthesis via direct administration of basic fibroblast growth factor int rat bone marrow.Micro Res Tech 41:313-322,1998
(*36)Nagai H, Tsukuda R et al. : Effects of basic fibroblast growth factor(BFGF) on bone formatiom in growing rats.Bone 16:367-373,1995
(*37)Martineau, Doize B, Lai WH et al. : In vivo demonstration of cell types in bone that harbor epidermal growth factor receptors.Endorinology 123:841-858,1988
(*38)Amizuka N, Ozawa H : Intracellular localization and translocation of 1 α,25(OH)2D3 receptor in osteoblasts.Arch Histol Cytol 55:77-88,1992
(*39)yosizawa T, Handa Y et al. : Mice lacking vitaminD receptor exhibit impaired bone formation,uterine hypoplasia and growth retardation after weaning. Nature Genetics 16:391-396,1997
(*40)St-Anaud R,Arabian A et al. : Abnomal bone development in mice deficlent for the vitaminD 24-hydroxylase gene. J Bone Miner Res 11:S126,1996
(*41)Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS : Estrogen resistance cused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 331:1056-1061,1994
(*42)Lubahn DB, moyer JS et al. : Alteration of reproductive of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Prc Nalt Aca Sci USA 90(23):11162-11166,1993
(*43)Ogawa S,lubahn DB et al. : behavioral effects of estrogen receptor gene disruption in made mice. Proc Nalt Aca Sci USA 94(4):1476-1481,1997
(*44)Belanger LF : Osteocytic osteolysis. Calcif Tissues Res 4:1-12,1969
(*45)Hamilton JA et al. : Stimulation of plasiminogen activator in osteoblast-like cells by bone-resorbing hormones. Biochem Biophys Res Commun 122:230-236,1984
(*46)Okada Y, Naka K et al. : localization of matrix metalloproteinase 9 (92=kilodation gelatinase/type W collagenase=gelatinase B) in osteoclasts : Implications for bone resorption. Laboratory Invest 72:311-323,1995
(*47)Brown EM, Vassilev PM et al. : Calcium ions as extracellular meaaengers. cell 83:679-682,1995
(*48)Pkllak MR, Brown EM et al. : Mutations in the human ca(2+)-sensing receptor genecause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 75:1297-1303,1993
(*49)真野博,前島明子ほか : 骨細胞(osteocyte)を介するシグナリング,骨形成・吸収のシグナリングと骨疾患. 実験医学 14(10):103-108,1996
(*50)Chambers TJ, Ali NN : Inhibition of osteoclastic motility by prostaglandins l2,E1,E2 and 6-oxo-E1. J Pathology 139:383-389,1983
(*51)Rawlinson SC, Mosley JR et al. : Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J Bone Miner Res 10:1225-1232,1995
(*52)Rawlinson SC, Mohan S et al. : Exogenous prostacyclin, but not prostaglandin E2,produces similar responses in bone G6PD activity and RNA production as mechanical loading, and increases lGF-ll release, in adult cancellous bone in culture. Calcif Tissue Int 53:324-329,1993
(*53)Chow JWM, Jagger CJ et al. : Reduction in dynamic indices of cancellous bone rat tail vertebrae after caudal neurectomy. Calcif Tissue Int 59;117-120,1996
(*54)Leen JM, Mackay AG et al. : Osteocytic expression of mRNA for c-fos and lGF-I : an immediate early gene response to an osteogenic stimulus. American J Physiol 270:E937-E945,1996
(*55)Ypey DL, Weidema AF et al. : Voltage,calcium,and stretch activated ionic channels and intracelllum in bone cells.J Bone Miner Res 7 Suppl2:S377-87,1992
(*56)Resnic N, Collins T et al. : Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Aca Sci USA 90:4591-4595,1993
(*57)Ejiri S, : The preosteoclast and its cytodiffereniation into the osteoclast : ultrastructural and histochemical studies of rat fetal parietal bone. Arch Histol Jap 46:533-577,1983
(*58)Katsunura N : 細胞タンパク質分解 - 機構・調節・病態 -, 120-124, 東京化学同人
(*59)Reponen P, Sahiberg C et al. : High expression of 92 kD type W collagenase ( gelatinase B ) in the osteoclast lineage during mouse development. J Cell Biol 124:1091-1103,1994
(*60)Baron r, Neff L et al. : Cell-mediated extracellular acidification and bone resorption : evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 101:2210-2222,1985
(*61)Salo J, Lehenkari P et al. : Removal of osteoclast bone resorption products by transcytosis. Science 276:270-23,1997
(*62)Nesbitt SA, Horton MA : Trafficking of matrix collagens through bone-resorbing osteoclasts. Science 276:266-269,1997
(*63)Burger EH, JWM van der Meer et al. : Osteoclast from mononuclear phagocytes : Role of bone-forming cells. J Cell Biol 99:1901-1906,1984
(*64)Takahashi N, Akatsu T et al. : Osteoblastic are involved in osteoclast formation. Endocrinology 123:2600-2602,1988
(*65)TakahashiN, Udagawa N et al. : Role of colony-stimulating factors in osteoclast development. J Bone Min Res 6:977-985,1991
(*66)Udagawa N, Takahashi N et al. : The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:1805-1813,1989
(*67)Udagawa N, Takahashi N et al. : The origin of osteoclasts : Mature monocyte-macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-stromal cells. Proc Natl Acad Sci USA 87:7260-7264,1990
(*68)Kodama H, Nose M et al. : Essential role of macrophage colony-stimulating factor in theosteoclast differentiation supported by stromal cells. J Exp Med 173:1291-1294,1991
(*69)Yasuda H et al. : Osteoclast differentiation is a ligand for osteoprotegerin/osteoclaastogenesis inhibitory factor and identical to TRANCE/RANKL Proc Natl Acad Sci USA 95:3597-3602,1998
(*70)Mizuno A, Amizuka N et al. : Severe osteoporosis in mice lacking OClF/OPG(Osteoclastgenesis inhibitory factor/Osteoprotegerin) . Biochem Biophys Res Commun 247(3) : 610-615,1998
(*71)Tondravi MM, McKercher SR et al. : Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature 386:81-84,1997
(*72)Home WC, Neff L et al. : Osteoclasts Express High Levels of pp60c-src in Association with intracellular Membrance. J Cell Biol 119:1003-1013,1992
(*73)Boyce BF, Yoneda T et al. : Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.J Clin Invest 90:1662-1667,1992
(*74)Warshawsky H, Goltzman D et al. : Direct in vivo demonstration by radioautography of specific binding sites for calcitonin. J Cell Biol 85:682-694,1980
(*75)Ikegami M, Ejiri S et al. : Histochemical and autoradiographic studies on Elcatonin in internalization and intracellular movement in osteoclasts. J Bone Miner Res 9(1):25-37,1994
(*76)Hara-Irie F, Amizuka N et al. : Immunohistochemical and ultrastructural localization of CGRP-positive nerve fibers at the distal trabecules facing the growth plate of rat femurs. Bone 18:29-39,1996
(*77)hughes DE, Wright KR et al. : Bisphosphonates promote apoptosis in murine osteoclastsin vitro and in vivo. J Bone Miner Res 10:1478-1487,1995
(*78)Fleisch H, Bisphosphonates - pharmacology and use in the treatment of tumor-nduced hypercalcemia and metastatic bone disease. Drugs 42:919-944,1991
(*79)Bilezikian JP : Management of acute hypercalcemia. N Engl J Med 326:1196-1203,1992
(*80)Anderson C, Cpe RDT, Crilly RG, et al. : Preliminary observations of a from of conherence therapy for osteoporosis. Calcif Tissue Int 36:341-343,1984
(*81)網塚憲生,伊東将広ほか : 骨と軟骨組織におけるアポトーシス,現代医療, アポトーシスと疾患 Vol29. No.1 現代医療社,1997


1.骨芽細胞の細胞機能

2.骨細胞の構造

3.骨芽細胞、骨細胞の機能を調節する因子:カルシウム調節因子

4.骨芽細胞と骨細胞によるカルシウムの流入、流出の調節機構について

5.骨芽細胞の微細構造と骨吸収機構

6.破骨細胞の分化および活性の制御について

おわりに

参考文献一覧